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KMID : 0380219940270060565
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Journal of Biochemistry and Molecular Biology
1994 Volume.27 No. 6 p.565 ~ p.568
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Stimulatory Effects of Thrombin on Inositor Phosphates Formation in Chinese Hamster Lung Fibroblasts which Overproduce Phospholipase C Isozymes
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Abstract
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Abstract:
@EN Thrombin as a mitogen elicits a number of physiological reactions, including phosphoinositides degradation in various tissues. To investigate whether different PLC isozymes are coupled to thrombin-induced inositol phosphates formation,
PLC-β1,
PLC-γ showed a significant increase in inositol phosphates formation. Stimulated inositol phosphates formation was not attributed to an increase in inositol phosphates formation. Stimulated inositol phosphates formation. Stimulated inositol
phosphates
formation was not attributed to an increase in phosphorylation of PLC. Phosphoinositides metabolism was not stimulated by treatment with proteolytically inactive thrombin. These findings suggest that thrombin-stimulated phosphoinositides
hydrolysis
is
coupled to PLC-β1, and that the proteolytic activity of thrombin has an important physiological role.
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KEYWORD
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